Due to an increase of fossil fuel usage and related emissions, there is growing motivation to develop more energy efficient engines as well as to identify suitable alternative fuels. Such efforts will require extensive modeling of the combustion of various fuels within the engine. Modeling efforts of internal combustion engines (ICEs) commonly use combustion models consisting of computational fluid dynamics (CFD) coupled with combustion kinetic models. Along with accurately capturing the spray physics and fluid dynamics, it is equally important for these combustion models to include validated chemical mechanisms for alternative fuels of interest. Such combinations allow for more efficient experimentation by identifying those conditions more likely to lead to engine control strategies for improved engine efficiency and reduced emissions.