This work is very much ‘in progress’ and is motivated by experimental results for mass transfer phenomena occurring at 10-100 nm length scales in cm scale milieus. Mass transfer membranes have been created with regular surface patterns that influence the deposition of colloidal species (10-1000 nm diameter). Our modeling work focuses on elucidating the role of fluid dynamics on these deposition effects (versus surface energy/adhesion). We are currently using CFD to compute the energy dissipation occurring at the surface of the patterns versus the angle of fluid ‘attack’, to determine whether or not these correlate with the experimentally-observed variations in the particle deposition. Our overarching goal is the development of a hybrid, multiscale, multiphysics solver to engineer nanoscale roughness specific for industrial applications.